Allulose: A Natural Sugar for Better Glycemic Control
One of the critical factors for the success of the Zone diet is improved glycemic control. This concept simply means that blood sugar levels are more stabilized from one meal to the next. The benefits are lack of hunger, better mental cognition, and reduction of inflammation. For decades, the diabetic research community has known that fructose has been the ideal simple sugar for better glycemic control. The reason is that fructose has a glycemic index that is five times lower than glucose. Consequently, this means less glucose enters the blood, and the result is better hormonal control. Part of the reason is that much of the dietary fructose never reaches the blood because bacteria metabolize it in the gut. That’s why I have always used fructose as a primary carbohydrate in Zone bars and shakes. It just makes scientific sense. Unfortunately, like politics, science is also prone to social media. In 2004, a short letter was written observing a correlation in the rise of obesity with the increase of high-fructose corn syrup (1). Keep in mind that high-fructose corn syrup is about 50 percent fructose and 50 percent glucose which is virtual identical to the composition of table sugar. Then came several popular diet books such as Fat Chance claiming our obesity epidemic is caused by fructose (2). One problem with that theory is that fruits are rich in fructose, and no one has ever advocated the stopping of fruit consumption. Another problem with that theory is that high-fructose corn syrup consumption peaked in 1999 and has declined by 40 percent since that time (3). Today the consumption of high-fructose corn syrup is below the level it was in 1990, and our obesity epidemic continues to increase. Rather than cursing the darkness of quasi-scientific misinformation, the best policy is to embrace new science. Now an alternative sweetener has come to market that might have even better glycemic properties than fructose. That’s why I am excited about allulose. Allulose is a natural sugar found in low quantities in various fruits. What is unique about allulose is that 90 percent never enters the blood and thus goes directly to the colon to improve gut health. Consequently, the FDA doesn’t consider allulose to be a sugar because it is not absorbed, but the FDA also doesn’t treat it as a fiber. It's like a “phantom” carbohydrate. However, what it does do in the gut is to increase AMPK levels (4). One of the consequences of activating AMPK is that you live longer (5). Thus, allulose can be considered an “anti-aging “sugar. Now that allulose can be produced in large amounts by biotechnology, it has been recently granted Generally Regarded as Safe (GRAS) status meaning it can be incorporated into food products. This opens up an entirely new potential for our next generation of Zone shakes and bars for enhanced glycemic control. For example, with the replacement of fructose by allulose in our ZoneRx shakes (currently available in Chocolate and Vanilla), the decrease in total carbohydrates now allows for the addition of extra berries to each shake to achieve a truly Zone balance. The amount of berries we recommend for better glycemic control is based on science not guessing. I recommend adding two blocks of berries (strawberries, blueberries, raspberries, or blackberries). That is also about 1 cup or about 6 oz of berries. This amount adds even more polyphenols and fermentable fiber to the final ZoneRx shake while maintaining the Zone macronutrient balance needed for optimal hormonal control. Of course, it also makes a complete meal that tastes likes a gourmet dessert in seconds. For maximum convenience, just purchase frozen berries (they have a higher nutrient quality than fresh berries) and keep enough already thawed in the refrigerator to make about two Zone shakes. As the leader in nutrition for the last 30 years, we are the first company to have shakes using allulose. Our ZoneRx bars containing allulose are under development and will be available shortly. The more science we can bring to your kitchen, the easier it becomes to retake control of your health by being in the Zone. ZoneRx Chocolate and Vanilla Shakes Now Contain Allulose References Bray GA et al. “Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity.” Am J ClinNutr 79:537-43 (2004) Lustig RH. Fat Chance. Penguin Books. New York, NY (2012) USDA Economic Research Service. “Per capita sweetener deliveries show steady downturn largely due to reduced demand for high fructose corn syrup.” Sugar and Sweetners Data (2021) Shintani T et al. “d-Allulose, a stereoisomer of d-fructose, extends Caenorhabditis elegans lifespan through a dietary restriction mechanism: A new candidate dietary restriction mimetic.” Biochem Biophys Res Commun 493:1528-1533 (2017) Ingram DK and Roth GS. “Glycolytic inhibition: An effective strategy for developing calorie restriction mimetics.” Geroscience https://doi.org/10.1007/s11357-020-00298-7 (2020)
Pregnancy Q&A With Dr. Sears
This week Dr. Sears answers questions he gets pertaining to diet and pregnancy. Learn about the role diet plays in fertility, conception and the health of mom and baby. Q: Dr. Sears we know that diet is important prior to conceiving and during gestation. What nutrients do you recommend women get enough of if they are thinking about conceiving or once they find out their pregnant? A: Infertility is a growing problem and I believe that inflammation is a major contributor to that situation. That’s why I recommend both females and males contemplating conception consume an anti-inflammatory diet. Such a diet is not to lose excess body fat, but to reduce inflammation and establish the hormonal balance that makes it more likely for successful procreation. Such an anti-inflammatory diet is adequate in low-fat protein, moderate in carbohydrates (but rich in fruits and vegetables), and low in fat (especially saturated fat). The most important supplement for both males and females to improve the success of conception would be omega-3 fatty acids because of their hormonal benefits in reducing inflammation in females and improving sperm quality in males. Once the mother is pregnant, her nutrition becomes paramount for the baby. This means following the same anti-inflammatory diet during pregnancy and especially focusing on fiber rich foods (especially fermentable fiber) for her gut health. Q: Most physicians recommend taking an omega-3 supplement when pregnant. Generally this is about 250-500mg or so of EPA and DHA. Do you think this is enough? A: I think that 250-500mg is too low a dose to reap all the benefits that come from omega-3 supplementation. For general wellness I recommend individuals consume about 3000 mg of EPA and DHA per day and this is the same amount I’d recommend for pregnant women too. Q: Do you need more omega-3s as pregnancy goes on or can you continue with the same dose? A: Throughout pregnancy I recommend women stay with the same dose of 3000 mg of EPA and DHA per day. This is because in the last trimester of pregnancy the fetus is making about 250,000 new brain cells per minute and that requires a lot of omega-3 fatty acids. Q: Once you deliver the baby can you stop taking omega-3s? A: I wouldn’t recommend it. Omega3 fatty acids only last about 24-48 hours in the blood so it requires you take a consistent dosage regularly. During the pregnancy, the fetus has been depleting the omega-3s from the mother’s reserve to develop its brain. What this means is that after the birth of the child, the mother can develop a sense of depression without continued omega-3 supplementation to replace her internal stores. I recommend staying either with the same dose or and you may even need to bump up the dosage after delivery especially if the mother is breast feeding to ensure adequate levels of EPA and DHA in her breast milk. I always recommend testing the levels of omega-3s in your blood to determine what dose is right for you by keeping your AA/EPA ratio between 1.5 and 3. Q: What are the benefits of omega-3s for both mom and child? A: EPA and DHA the omega-3s found in fish oil are known for their role in supporting heart health, a healthy immune system and inflammatory response as well as supporting eye and brain development. They’ve also been shown to help minimize the risk of allergies in children. They work by increasing the production of the hormones known as resolvins that are key to maintaining low levels of inflammation in both the mother and the child. Q: What do you look for in an omega-3 supplement? A: The vast majority of fish oil products use the same raw material (sardines and anchovies), but what separates one from the other is their purification to remove toxins that are found in all fish oil products. Polychlorinated biphenyls (PCBs), are the most difficult toxins to remove from fish oil. That is why my standards for PCBs (less than 2 parts per billion) are 25 times more stringent than pharmaceutical standards and 45 times more rigid than those established for the dietary supplement industry. You also want to look at the total amount of EPA and DHA since that is where the health benefits of omega-3s come from. OmegaRx 2 supplies 750mg of EPA and DHA per gram (1 capsule). This is the highest purity fish oil with the highest amounts of EPA and DHA currently offered in the marketplace without a prescription. Each serving of OmegaRx 2 (4 capsules or 1 tsp) supplies 3000mg of EPA and DHA. Purity and potency are most important when looking to take an omega-3 supplement. But you also have to look at the price. Based on the cost per gram of EPA and DHA, OmegaRx 2 is probably the least expensive source of EPA and DHA (based on cost per gram) with the highest purity and the greatest potency. Q: When you have morning sickness the last thing you can stomach is fruits, vegetables or even protein. It seems like crackers and ginger ale becoming the diet of choice. What do you recommend for women with morning sickness? A: Pregnancy isn’t easy and morning sickness can be unbearable for some women. Morning sickness tends to decline as the pregnancy continues. My recommendation is try and keep up with your omega-3s and prenatal vitamin to cover your bases and the meals where you are feeling good try and get in as many vegetables and fruits you can even if it’s by adding it to a shake, with some protein powder, and some monounsaturated fat. Q: Can fish oil help with some of the aches and pains of pregnancy? A: Yes. Carrying around extra weight can take its toll especially in pregnancy with the pressure on the joints and stretching. The anti-inflammatory properties of omega-3 fatty acids have been shown to help with joint support and to help minimize some of the inflammation that results in pain. Q: Women who might not struggle with high blood sugar or high blood pressure prior to becoming pregnant might start to have these numbers creep up during pregnancy or even lead to gestational diabetes and pre-eclampsia. Can diet and supplementation help? A: The Zone diet is really ideal for individuals who are looking to support healthy blood pressure and healthy blood sugar. The Zone diet is not a weight loss diet, but an anti-inflammatory diet. I like to think of it as an anti-inflammatory lifestyle.Inflammation underlies many of these conditions associated with pregnancy. Omega-3s have been clinically shown to help support healthy blood pressure. Polyphenols which give fruits and vegetables their color, especially polyphenols found in berries known as delphinidins, may further help with blood sugar control. That’s why I consider all three dietary components (diet, omega-3 fatty acids, and polyphenols) to be important during pregnancy as well as afterwards whether the mother is nursing or not. Q: If you can’t swallow fish oil capsules, what would you recommend? A: Liquid fish oil is a great alternative for individuals who can’t swallow capsules or who require higher amounts of omega-3s. You can add the liquid omega-3 fatty acids to some high-quality olive oil (rich in polyphenols) and take it orally. Better yet, you can make an emulsion by adding some dry lecithin to about 3-4 ounces of water and the liquid omega-3 and then blend them with a high-speed hand blender. If you can swallow smaller capsules, but not the standard size microcapsules might be an option too.
Cocoa Benefits Q and A
Dr. Sears answers some of the top questions we receive about our new Cocoa Polyphenols. Q: What are the health benefits of cocoa? A: The health benefits of cocoa come from the polyphenols it contains. Studies link cocoa consumption to improved cardiovascular health, increased cognition, enhanced blood flow, reduced insulin resistance, anti-aging benefits, and a healthy gut. Q: What is the difference between cacao, cocoa, and chocolate? A: In short, the level of processing defines the difference between cacao, cocoa and chocolate in addition to the amount of polyphenols. Cacao is the name of the tree that chocolate comes from. The cacao tree produces pods which contain cacao beans that can be turned into cocoa and further processed into chocolate. Steps During Processing Cacao beans are sorted, cleaned and dried. The shells are then removed (winnowed) to produce cacao nibs which are roasted to further enhance flavor and aroma. Cacao nibs are then ground into a liquid mass called chocolate liquor (no alcohol here). Chocolate liquor can be made directly into chocolate or further refined through a pressing process to extract the cocoa butter from the cocoa solids. The cocoa solids can be pulverized into cocoa powder, which retain the remaining polyphenol content in dry form. The cocoa butter can then be added back in defined amounts to the chocolate liquor to make various grades of chocolate. The amounts of chocolate liquor, cocoa butter and cocoa solids differentiates the type of chocolate to be made (white, milk, dark). *Note: Before being processed into chocolate, cacao beans go through a fermentation process. This can greatly reduce the polyphenol content in the cacao beans. This is why Zone Labs uses unfermented cacao beans when making our cocoa extract. Q: What is cocoa extract? A: We developed a proprietary cocoa extract using a purification process that allowed us to retain the maximum polyphenol content while minimizing the amount of cadmium, a heavy metal found in all cocoa products. Q: Is there a benefit of using cocoa extract over consuming cacao nibs which are considered the purest form of chocolate? A: In order to gain all the health benefits that come with cocoa polyphenols you need to eat large amounts of cocoa. What most people don’t know is that all cocoa products are contaminated with heavy metals. One of the major considerations when consuming cacao nibs and cocoa powders is that they naturally contain cadmium, a heavy metal associated with kidney toxicity. This means higher intakes of cocoa polyphenols could come with high intakes of cadmium. This is what makes using cocoa extracts like CacaoRx desirable because they’ve been purified to minimize the intake of heavy metals while retaining the maximum amount levels of polyphenols. Q: Does the level of cocoa polyphenols differ with the type of chocolate? A: Yes, generally cacao nibs have the highest levels of polyphenols followed by cocoa powder, dark chocolate, and milk chocolate (very few). White chocolate has no polyphenols. Q: What is CacaoRx? A: CacaoRx is a high purity, high-potency cocoa polyphenol extract. I developed CacaoRx using a process to reduce heavy metals such as cadmium that are commonly found in cocoa products. Q: What is CacaoRx Plus? A: CacaoRx Plus is high purity, high-potency cocoa polyphenol extract combined with our purified maqui extract (MaquiRx). The addition of maqui helps maximize the absorbable amount of polyphenols that enter the bloodstream to bring out the health benefits associated with cocoa. Q: Do CacaoRx and CacaoRx Plus use cacao powder or cocoa powder? A: The starting material for CacaoRx and CacaoRx Plus is our proprietary cocoa powder. Q: Do you test the heavy metal content of your products? A: Yes, all of our products using cocoa are 3rd party tested for purity and potency. Q: Can you bake with CacaoRx or CacoaRx Plus? A: While you could bake with our cacao products, we don’t recommend it because exposing cocoa polyphenols to high heat will destroy some of the polyphenols in the product. Q: Do CacaoRx and CacaoRx Plus contain caffeine? A: The cocoa used in these products is highly purified to remove heavy metals while retaining polyphenol content. There is some caffeine and theobromine but in very low concentrations. Q: Are CacaoRx and CacaoRx Plus safe for children in supplement form? A: We always recommend that prior to starting supplementation individuals consult their physician. All of our cocoa polyphenol products have Generally Recognized as Safe (GRAS) status which means they have undergone an extensive external review of their production and safety so that they can be incorporated into food products. Q: Are CacaoRx and CacaoRx Plus Non-GMO? A: Yes, these are non-GMO. Q: If you use CacaoRx or CacaoRx Plus, do you still need to supplement with polyphenols? A: I recommend individuals consume at least 1,000 mg of polyphenols per day for wellness and about 1,500 mg per day for anti-aging to help with stimulation of AMP kinase*. To get those levels, one would need to eat about 10 servings of non-starchy vegetables and fruits. Reaching those levels with food alone is difficult. Furthermore, many of the sources rich in polyphenols either have pesticide contamination or heavy metal contamination. For example, strawberries and spinach are good sources of polyphenols, but each is often rich in pesticides. Cocoa powder which is the basic component of chocolate products is often rich in the heavy metal cadmium. The cocoa extract we use in CacaoRx and CacaoRx Plus is highly purified and has GRAS status meaning it has passed strict testing to be able to be used in food products. It is the type of polyphenols you consume that makes the most difference. I feel that polyphenol extracts such as those found in CacaoRx and MaquiRx have the most benefits. Maqui berry extract is considered the best of the best as it’s rich in delphinidins and helps support improved blood sugar control, and cocoa extracts like those in CacaoRx help support improved blood flow and the reduction of insulin resistance. Both of these polyphenol extracts have been supported by clinical studies. Q: How many polyphenols come from maqui vs. cocoa in the CacaoRx Plus? A: Each capsule of CacaoRx Plus contains 150 mg of total polyphenols. The majority of the polyphenols come from cocoa and the rest from maqui. The exact amounts we use are proprietary. Cocoa is not highly absorbed which helps to promote the good bacteria in our guts while maqui is a polyphenol known to be more absorbable in the blood. The combination of the two helps to support the hormones in both the gut and the blood. The polyphenols in CacaoRx Plus are 3 times more absorbable compared to CacaoRx.
Dr. Sears' Polyphenol Q & A
Dr. Sears answers some of the top questions we receive about polyphenols and what makes MaquiRx unique. What are Polyphenols? Polyphenols are complex phytochemicals produced by plants to offer them protection against the sun's radiation and to help defend against injuries induced by microbes or bacteria. Just like polyphenols protect plants, they protect us in a similar way by acting as antioxidants to help combat inflammation and aid in supporting immunity through their activation of key genes. They also play a key role in gut health by helping to defend against bad bacteria while increasing the production of good bacteria. What are the health benefits of consuming polyphenols? Polyphenols should be considered essential nutrients since we know they function as activators of key gene transcription factors such as AMP-Kinase and support the following benefits: What is responsible for all the benefits of polyphenols? Polyphenols, at adequate nutritional intakes, support the activation of AMP-Kinase. Think of AMP-kinase like a genetic master switch for your metabolism. The greater its activity the longer your health span. Which foods contain polyphenols? The more colorful the plant, generally the higher the polyphenol content. This is why fruits, especially berries, and vegetables are good sources of polyphenols. Nonetheless, the levels of polyphenols occurring in fruits and vegetables is only between 0.1 and 0.2 percent by weight. Polyphenols are also found in cocoa, legumes, spices, and plant derived beverages such as tea, coffee and wine. How much should people consume? The answer depends on your personal goals. There are reported benefits that come with consuming anywhere between 500mg to 1,500mg of polyphenols per day. I recommend aiming for a minimum of 1,000mg per day for general wellness. To give a sense of what 1,000mg of polyphenols per day looks like, it could be approximately 5 ½ cups of broccoli, 1 ½ cups of blueberries, 2 ¼ cups of strawberries, or a combination of various fruits and vegetables. A good rule of thumb is that consuming 10 servings of vegetables and fruits per day will provide about 1,000mg of polyphenols per day. Can you get enough polyphenols through your diet? Only 1 out of every 10 adults in the U.S. meets the recommended intake of fruits and vegetables (5 servings per day) let alone the 10 servings per day that I recommend. Unfortunately, the fruits and vegetables that are usually consumed tend to be high in carbohydrates and low in polyphenols. Examples would include bananas and potatoes that can rapidly increase blood sugar levels leading to increased insulin levels. This is why supplementing with purified polyphenol extracts will have the least adverse effect on blood sugar levels. Are some polyphenols better than others? Yes. There are about 8,000 known polyphenols from a wide variety of sources. I consider the best dietary sources are from the blueberry family. The polyphenols in the blueberry family include: American blueberries, Russian blueberries (bilberries), and the Patagonia blueberry (maqui berries). Maqui berries have the highest concentration of a subclass of polyphenols called delphinidins which are water-soluble, meaning they are more likely to get into the blood and have been shown to help support improved blood sugar levels and reduced oxidative stress in clinical studies. What is Maqui? Maqui Berry is the richest antioxidant source in the world, having three times more antioxidants than blackberries, blueberries, strawberries and raspberries. Furthermore, maqui berries are the richest known source of delphinidins. Why extracts over powder or juice? Polyphenol extracts significantly increase the levels of polyphenols and reduce their carbohydrate content. Extracts are more concentrated and purified than simply a juice or a dry powder made from a juice. With extracts, the dry powder of the fruits is further extracted to increase the polyphenol content. For the most purified extracts (such as MaquiRx), the final concentration step involves a complex purification process that produces a refined extract that has about a 40% concentration of polyphenols by dry weight. Such extracts from maqui berry have 14 times more delphinidins compared to common blueberries. Maqui berry extracts have been shown to help activate AMP-Kinase which plays a key role in energy balance and metabolism. Activation of AMP-Kinase is the genetic master switch that controls appetite, blood sugar, lipid levels, reduction of inflammation, and repair of damaged tissue. Research has shown that delphinidins in purified maqui extracts can enter the blood more easily than other polyphenols, thus supporting activation of AMP kinase. Is there a blood test to measure how many polyphenols I need? There is no specific test to measure polyphenols in the blood since their lifetime in the body is short. That said, there is a standard test you can take to gauge whether you are taking enough. This is called hemoglobin A1c (HbA1c). HbA1c is a measure of the circulating levels of blood glucose over a 3-month period of time. If you can maintain a HbA1c level between 4.9-5.1% you are probably doing a good job getting enough polyphenols through diet and supplementation. If your HbA1c levels are higher, you probably need to add more polyphenols to your diet. Dr. Sears recommends consuming 1000mg of polyphenols a day. Each maqui capsule supplies 120mg of polyphenols. Does that mean you need 8 capsules per day? No. Ideally your polyphenol intake should come from a combination of both food and supplementation. It really depends on how much you think you can consume in your diet. The more fruits and vegetables you consume following the Zone Diet, the less polyphenol extracts you need. When will people start seeing the benefits after they begin to supplement? Generally within 30 days of using MaquiRx you’ll begin to notice benefits in the improvement of your metabolism. Are there any side effects to supplementing with polyphenols? No, as long as the polyphenols are highly purified such as MaquiRx and you can keep your HbA1c in the desired range of 4.9-5.1% there will not be any issues. At lower levels of HbA1c there is the possibility that the body may increase the secretion of cortisol to increase blood sugar levels. This is common for individuals following ketogenic diets. How long do you have to take it? Polyphenols should be considered essential nutrients that must be supplied by the diet for a lifetime.{{cta('b55efb49-3acd-41bc-ac18-721609a63a24')}}
Evolution of the Zone: Making Diet Work for a Lifetime
The word diet often has negative connotations. It is often thought of as a period of constant hunger and fatigue to get into a swimsuit. People often also regain all the lost weight and more after stopping the diet. A recent article reinforces this idea in Obesity that demonstrates the contestants in the Biggest Loser television series had virtually regained all their lost weight in a six-year period. This was followed by an article in the New York Times entitled, “Why You Can’t Lose Weight on a Diet.” What Does the Word Diet Really Mean? The word diet comes from the Greek root, which means “way of life.” This means that a diet should be followed for your lifetime, depending on your goal. The American Heart Association diet, the American Cancer Association diet, and the American Diabetes Association diet were all designed to prevent or treat a particular condition and should be followed for life. The Mediterranean diet is to be followed for a healthy life. And of course, the Zone Diet is to be followed for a lifetime to maintain inflammation in a manageable range consistent with optimal wellness. The Secret to Making Your Diet Work The secret to maintaining any diet, whatever the goal, is that you can’t be hungry or fatigued. But hunger and fatigue don’t just mysteriously appear; they are symptoms that indicate that your diet is not working. Hunger and fatigue are the consequence of increased inflammation in your gut, your organs, and your brain. There are many causes of inflammation that you will never see on social media or in academic journals because it is overwhelming. Here are just a few: Excess dietary omega-6 fatty acids increases the production of pro-inflammatory eicosanoids. Excess dietary palmitic acid increases inflammation in the hypothalamus, causing hunger. Increased gut permeability caused by lack of dietary fermentable fiber that leads to increased bacterial fragments entering the blood, causing metabolic endotoxemia (the release of toxins into the blood from gut bacteria). Excess dietary fat that increases the transport of bacterial fragments into the blood cause even more metabolic endotoxemia. Excess consumption of dietary calories causing inflammation in the hypothalamus, increasing hunger. Lack of adequate levels of dietary polyphenols to control the microbial composition of the gut and reduce oxidative stress in the body. Lack of adequate levels of dietary omega-3 fatty acids to reduce inflammation and increase resolution in the gut, blood, and the brain. You can see the word dietary appearing over and over in these various causes of inflammation. This indicates that most of our woes in our health care system are a consequence of the diet. Unless you address each of these diet-induced causes of inflammation, you are going to have hard time maintaining optimal wellness. This is the challenge I took on when developing the Zone Diet. The Zone Diet is Even Easier Now First and foremost, the Zone Diet is based on calorie restriction, but without hunger and fatigue. The first generation of the Zone Diet required a person to constantly pay attention to balancing protein, carbohydrate, and fat at every meal. In addition, I took out the three things (pasta, pizza, and pastries) in the diet people really like to eat. I guess my tough love was a little too much for busy people who needed easy short fixes resulting in long-term solutions. I could just say, “too bad,” or I could try to solve the problem with the evolution of the Zone Diet. I choose the latter approach. This choice led to the development a new series of protein-based foods that could take the place of non-sustainable animal protein. Furthermore, these new foods were in a format that would be more convenient and more desirable than the foods people were already eating. After all, that is the only way to encourage people to make dietary changes. The resulting diet would have to create far greater appetite suppression with even greater energy compared to the first generation of the Zone ̶ a formidable challenge to undertake, but not an impossible one to achieve. What made it possible was the patented technology to create Zone PastaRx®. Zone PastaRx looks and tastes like the foods that in the past always made you put on body fat, but now they make you leaner. Why? Because PastaRx is able to suppress appetite and stabilize blood sugar levels with improved hormonal control. This evolution of the Zone Diet changes the hormones in three areas of the body (gut, blood, and the brain), whereas the original Zone Diet could only change the hormones in the blood. In effect, this evolution of the Zone has three times the hormonal benefits using the foods you like to eat as a novel protein source. What if you ate a diet consisting of Zone PastaRx with some non-starchy vegetables (for the fermentable fiber) for lifetime with the result of never being hungry or fatigued? Furthermore, what if dozens of recipes were already tested and posted online so you don’t have to even think about variety? I am taking a wild guess that most people could follow such a diet for a lifetime. By following this next generation of the Zone Diet, you will reduce diet-induced inflammation that is the underlying cause of the development of chronic disease, as well as the acceleration of the aging process. If you add high-doses of purified omega-3 fatty acids (OmegaRx®) and purified polyphenol extracts, you simply take those inflammation control benefits from the next generation of the Zone Diet to new higher level. Studies Have Shown that PastaRx Reduces Insulin Resistance The motto of Zone Labs is Evidence-based Wellness®. This simply means, “show me the data.” In two clinical experiments using Zone PastaRx, we observed dramatic reductions in the level of insulin resistance in obese subjects using meals consisting of Zone PastaRx when compared to control groups using gluten-free pasta. Inflammation is what causes insulin resistance. In fact, the reduction in insulin resistance in the subjects consuming Zone PastaRx was equal to that of giving insulin injections for newly diagnosed type 2 diabetic patients according to a study. I think you can see why I believe the future for the evolution of the Zone Diet is extremely bright; because Zone Pasta makes diets work.{{cta('cd305230-6e34-42f6-9e2c-c2beda556f50')}} References: Fothergill E et al. “Persistent metabolic adaption 6 years after ‘The Biggest Loser’ competition.” Obesity 24: doi: 10.1002/oby.21538 (2016). Aamodt S. “Why you can’t lose weight on a diet”. New York Times. May 6, 2016. Sears B and Perry M. “The role of fatty acids in insulin resistance.” Lipids Health Dis 14:121 (2015). Wang D et al. “Effects of intensive insulin therapy upon pancreatic β cell function in patients newly diagnosed with type II diabetes”. Int J Clin Exp Med 8:1391–1395 (2015).
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