zone_blog_lifetime_diet-online-1

Evolution of the Zone: Making Diet Work for a Lifetime

The word diet often has negative connotations. It is often thought of as a period of constant hunger and fatigue to get into a swimsuit. People often also regain all the lost weight and more after stopping the diet.

A recent article reinforces this idea in Obesity that demonstrates the contestants in the Biggest Loser television series had virtually regained all their lost weight in a six-year period. This was followed by an article in the New York Times entitled, “Why You Can’t Lose Weight on a Diet.”

What Does the Word Diet Really Mean?

The word diet comes from the Greek root, which means “way of life.” This means that a diet should be followed for your lifetime, depending on your goal.

The American Heart Association diet, the American Cancer Association diet, and the American Diabetes Association diet were all designed to prevent or treat a particular condition and should be followed for life. The Mediterranean diet is to be followed for a healthy life. And of course, the Zone Diet is to be followed for a lifetime to maintain inflammation in a manageable range consistent with optimal wellness.

The Secret to Making Your Diet Work

The secret to maintaining any diet, whatever the goal, is that you can’t be hungry or fatigued. But hunger and fatigue don’t just mysteriously appear; they are symptoms that indicate that your diet is not working. Hunger and fatigue are the consequence of increased inflammation in your gut, your organs, and your brain.

There are many causes of inflammation that you will never see on social media or in academic journals because it is overwhelming. Here are just a few:

  • Excess dietary omega-6 fatty acids increases the production of pro-inflammatory eicosanoids.
  • Excess dietary palmitic acid increases inflammation in the hypothalamus, causing hunger.
  • Increased gut permeability caused by lack of dietary fermentable fiber that leads to increased bacterial fragments entering the blood, causing metabolic endotoxemia (the release of toxins into the blood from gut bacteria).
  • Excess dietary fat that increases the transport of bacterial fragments into the blood cause even more metabolic endotoxemia.
  • Excess consumption of dietary calories causing inflammation in the hypothalamus, increasing hunger.
  • Lack of adequate levels of dietary polyphenols to control the microbial composition of the gut and reduce oxidative stress in the body.
  • Lack of adequate levels of dietary omega-3 fatty acids to reduce inflammation and increase resolution in the gut, blood, and the brain.

You can see the word dietary appearing over and over in these various causes of inflammation.

This indicates that most of our woes in our health care system are a consequence of the diet. Unless you address each of these diet-induced causes of inflammation, you are going to have hard time maintaining optimal wellness. This is the challenge I took on when developing the Zone Diet.

The Zone Diet is Even Easier Now

First and foremost, the Zone Diet is based on calorie restriction, but without hunger and fatigue. The first generation of the Zone Diet required a person to constantly pay attention to balancing protein, carbohydrate, and fat at every meal. In addition, I took out the three things (pasta, pizza, and pastries) in the diet people really like to eat.

I guess my tough love was a little too much for busy people who needed easy short fixes resulting in long-term solutions. I could just say, “too bad,” or I could try to solve the problem with the evolution of the Zone Diet. I choose the latter approach.

This choice led to the development a new series of protein-based foods that could take the place of non-sustainable animal protein. Furthermore, these new foods were in a format that would be more convenient and more desirable than the foods people were already eating. After all, that is the only way to encourage people to make dietary changes. The resulting diet would have to create far greater appetite suppression with even greater energy compared to the first generation of the Zone  ̶  a formidable challenge to undertake, but not an impossible one to achieve.

What made it possible was the patented technology to create Zone PastaRx®. Zone PastaRx looks and tastes like the foods that in the past always made you put on body fat, but now they make you leaner.

Why? Because PastaRx is able to suppress appetite and stabilize blood sugar levels with improved hormonal control. This evolution of the Zone Diet changes the hormones in three areas of the body (gut, blood, and the brain), whereas the original Zone Diet could only change the hormones in the blood. In effect, this evolution of the Zone has three times the hormonal benefits using the foods you like to eat as a novel protein source.

What if you ate a diet consisting of Zone PastaRx with some non-starchy vegetables (for the fermentable fiber) for lifetime with the result of never being hungry or fatigued?

Furthermore, what if dozens of recipes were already tested and posted online so you don’t have to even think about variety?

I am taking a wild guess that most people could follow such a diet for a lifetime. By following this next generation of the Zone Diet, you will reduce diet-induced inflammation that is the underlying cause of the development of chronic disease, as well as the acceleration of the aging process. If you add high-doses of purified omega-3 fatty acids (OmegaRx®) and purified polyphenol extracts, you simply take those inflammation control benefits from the next generation of the Zone Diet to new higher level.

Studies Have Shown that PastaRx Reduces Insulin Resistance

The motto of Zone Labs is Evidence-based Wellness®. This simply means, “show me the data.”

In two clinical experiments using Zone PastaRx, we observed dramatic reductions in the level of insulin resistance in obese subjects using meals consisting of Zone PastaRx when compared to control groups using gluten-free pasta. Inflammation is what causes insulin resistance.  In fact, the reduction in insulin resistance in the subjects consuming Zone PastaRx was equal to that of giving insulin injections for newly diagnosed type 2 diabetic patients according to a study.

I think you can see why I believe the future for the evolution of the Zone Diet is extremely bright; because Zone Pasta makes diets work.{{cta('cd305230-6e34-42f6-9e2c-c2beda556f50')}}

References:

  1. Fothergill E et al. “Persistent metabolic adaption 6 years after ‘The Biggest Loser’ competition.” Obesity 24: doi: 10.1002/oby.21538 (2016).
  2. Aamodt S. “Why you can’t lose weight on a diet”. New York Times. May 6, 2016.
  3. Sears B and Perry M. “The role of fatty acids in insulin resistance.” Lipids Health Dis 14:121 (2015).
  4. Wang D et al. “Effects of intensive insulin therapy upon pancreatic β cell function in patients newly diagnosed with type II diabetes”. Int J Clin Exp Med 8:1391–1395 (2015).

Leave a comment

More Articles

022724---Weight-Loss-Blog

Dr. Sears Q&A: Weight Loss

With so much interest in weight loss and so much buzz around weight loss drugs, we put together some of the top questions we get in this latest Q&A blog. Here Dr. Sears answers your questions on weight loss, weight loss drugs and what he thinks is the most scientifically backed way to lose weight. See what he has to say.Question: What medical conditions could impede weight loss, and how can they be identified?  Answer:  Any condition associated with insulin resistance will make it difficult to lose weight.  This would include diabetes, heart disease, neurological disease, etc.  Also, any drug that induces insulin resistance will also make it difficult to lose weight.  These include corticosteroids and many neurological drugs. Question: How do hormones affect weight loss, and which imbalances are most detrimental? Answer: High levels of insulin (caused by insulin resistance), high levels of cortisol (caused by stress), and low levels of satiety hormones such as GLP-1 will make weight loss difficult. Question: Is there a connection between sleep quality and weight loss? Answer: Poor quality sleep increases cortisol levels that lead to insulin resistance. The higher your level of insulin resistance, the more difficult it is for any organ to remove glucose from the blood for transport into the cell, where it can be converted to energy. This i Question: Do any weight loss supplements work?  Answer: Not really. You have to restrict calories to activate AMPK which causes your body to effectively burn excess stored body fat.   Question: What medications are FDA approved for weight loss? Answer: There are number of approved older drugs, but the most widely used is still an old drug (Phentermine) that was only recently approved for long-term use. However, the new injectable GLP-1 receptor agonists are more powerful and more popular. The scientific name for the most well-known injectable weight-loss drug is semaglutide, which is marketed under the tradenames Ozempic and Wegovy. In simple terms, these injectable drugs activate the release of the hormone GLP-1 from the gut that goes directly to the brain to tell you to stop eating. These drugs were initially developed to treat type 2 diabetes, but the clinical studies in overweight and obese individuals demonstrated significant weight loss at higher levels. Question: What are the unintended side effects of weight loss medications (i.e. GLP-1s, dual GIP/GLP-1). Answer: One major problem is that the lack of hunger caused by the drug makes you less likely to consume sufficient protein to maintain lean body mass.  Lean body mass is defined as functional tissue such as organs (including the brain) and bone.  Nearly 40 percent of the weight loss in obese patients comes from loss of lean body mass.  Without adequate protein (especially on a diet that is calorie-restricted because of lack of hunger), the replacement of damaged cells is compromised.  The skin and hair are the first site to suffer.  This lack of protein also makes it difficult to maintain mitochondrial function that provides energy for each of your 30 trillion cells. As a result, fatigue (both mental and physical) is often experienced. Question: Would you recommend an injectable weight loss drug? Answer: The answer is no. There is a big difference between weight loss and fat loss. Weight loss is the combined loss of stored body fat and lean body mass (i.e., muscle). You want to lose fat but not muscle. Although the weight loss using weekly semaglutide injections is impressive according to the literature, a deeper look shows that about 40 percent of that weight loss is due to loss of lean body mass. That is not a good sign. It suggests that the injections reduce hunger to the extent that the person has little desire to eat enough protein to maintain muscle mass. In essence, the drug increases the patients' sarcopenia (muscle loss). One of the consequences of sarcopenia is increased frailty. Also once you stop using these weight loss drugs, the weight quickly returns. Question: Does a high protein diet help with weight loss? Answer: Most high protein diets are ketogenic diets that disrupt metabolism in addition to being high fat.  The appropriate diet is protein-adequate (about 30 grams of protein at each meal), carbohydrate-moderate (primarily non-starchy vegetables, low-fat (to reduce calories) and rich in fermentable fiber.  The common name for such a diet is the Zone diet. The ideal amount of protein at each meal for weight loss is about 30 grams. Less than 30 grams of protein at meal will not generate the hormonal signals from the gut to stop hunger. Too much protein at meal, greater than 30 grams, will inhibit AMPK activity which helps cells burn excess stored fat.  

View Article
020524-Winter-E-Newsletter-Blog-4

Aging: Can You Slow It Down?

The first few weeks of the New Year are often focused on the resolve to lose weight, when in actuality people should focus their goals on slowing down aging, no matter the time of year. The only regimen that clinically achieves results in slowing the aging process is calorie restriction without malnutrition. Why? It’s not simply losing weight but orchestrating the complex interplay of reducing senescent cells, reprograming your metabolism, and changing gene expression, leading to a longer and better life.   A Timeline of Calorie Restriction   The first recorded human experiments with calorie restriction began with the written books of Luigi Cornaro in the 16th century, as I outlined in my book The Anti-Aging Zone, published in 1999. However, the molecular mechanisms of why calorie restriction is so effective required more recent breakthroughs in metabolism and epigenetics that were confirmed with the CALERIE study that carefully controlled the diets of 225 participants over two years and then ongoing testing of their retained blood samples.     The results of the CALERIE study have been impressive. However, the one clear take-home lesson was that reduction of insulin resistance was the most predictive blood marker correlated with the genetic changes and the decrease in senescent cells that ultimately accelerate aging.   The Zone on Calorie Restriction   The Zone diet is a calorie-restricted diet that was patented to reduce insulin resistance. It requires balancing macronutrients at each meal to generate the rapid hormonal changes that give rise to satiety. Only then can you follow calorie restriction for a lifetime without hunger and fatigue. It starts with having enough protein at each meal to create satiety in the brain's appetite control center. You need about 30 grams of protein (no more, but no less) at each meal to generate the same hormonal responses induced by the recent injectable weight loss drugs. However, you also must balance that protein with an adequate level of low-glycemic carbohydrates (about 40 grams) to stabilize blood glucose levels, and then add a dash of monounsaturated fat (about 15 grams). Over the years, it has been demonstrated by more than 40 research publications that the Zone diet is superior to ketogenic diets and the Mediterranean diet under controlled clinical research.    A New Technology to Slow Down Aging  Unfortunately, many people think the Zone diet requires too much thinking.  That’s why I developed Zone Foods to overcome that problem. The first generation of Zone Foods demonstrated dramatic reductions in insulin resistance compared to a control group, getting an equal number of calories (1). The second generation of Zone Foods offers greater variety and even more appetite suppression without thinking. This second generation will include new and improved versions of the Zone Pasta and Zone Bars, with new additions of Zone Muffins, Zone Oatmeal, Zone Granola, Zone Soups, and Zone Cookies (coming soon!). Each Zone Food contains 15 grams of protein, balanced with the appropriate level of low-glycemic carbohydrates, so any combination of two Zone Foods will provide the critical 30 grams of protein at a meal to stop hunger and maintain peak mental awareness for the next five hours. The growing variety of Zone Foods makes following the Zone diet incredibly easy. If you are never hungry, that indicates that you are reducing insulin resistance. The long-term benefit to you is slowing aging, which is only possible with lifelong use of Metabolic Engineering that starts with the Zone diet as its foundation. You May Also Like: Reaching the Zone Using Metabolic Engineering

View Article