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Dr. Barry Sears Answers Your Questions on Omega-3 Fish Oil

 Dr. Sears answers some of the top questions we receive about fish oil and omega-3 fatty acids and what makes OmegaRx 2 unique.  

What are EPA and DHA?
EPA is an abbreviation for the omega-3 fatty acid Eicosapentaenoic Acid. DHA is short for Docosahexaenoic Acid. The anti-inflammatory properties of fish and fish oil are mainly due to these two omega-3 fatty acids. The benefit of EPA and DHA comes from reducing cellular inflammation by inhibiting the formation of inflammatory hormones (e.g. eicosanoids) derived from the omega-6 fat, Arachidonic Acid (AA).  However, their greatest benefits come from the generation of pro-resolution hormones (i.e. resolvins) that turn off the inflammatory process.  

If someone considers themselves healthy, why would they need to take omega-3 fatty acids?
Omega-3 fatty acids are considered essential fatty acids meaning they must be supplied in our diets. They are the building blocks for hormones that resolve existing inflammation. Unresolved inflammation is the primary reason we gain weight, develop chronic disease, and age at a faster rate. The typical American diet is very low in omega-3 fatty acids and rich in omega-6 fatty acids (the building blocks for pro-inflammatory hormones). This is why you need a high concentration of purified omega-3 fatty acids to make a difference in addition to lowering the levels of omega-6 fatty acids in the diet.

Why is fish oil superior to krill oil, flaxseed or other omega-3 products on the market?
Fish oil is made by heating fish to release the stored fats. From this crude fish oil, the omega-3 fatty acids can be further refined/purified into omega-3 concentrates. Krill oil is actually made of small shrimp that have been harvested and extracted using harsh chemicals (hexane and acetone). Furthermore, the omega-3 fatty acid content in krill oil is much lower than in omega-3 concentrates derived from fish oil. Flax seed oil is rich in alpha-linolenic acid (ALA). Although ALA is an omega-3 fatty acid, it has no health benefits unless converted into EPA and DHA. This conversion is very inefficient (about 1-10%) so you would have to consume large quantities to get the same benefits of a much smaller amount of omega-fatty acid concentrates.  

What is it about OmegaRx2 that makes it different from other brands?
The answer is purity and potency. OmegaRx 2 is highly purified to remove as many PCBs as possible and our standards are eighteen times more rigid than the industry standards. In addition, Zone Labs publishes the purity data for every lot of OmegaRx 2 on our website to give our customers total transparency. All omega-3 fatty acids are prone to oxidation which is why we publish the levels of stability (defined by the TOTOX level or rancidity in layman terms) on every lot of OmegaRx2 as well.  Our post production levels of rancidity are among the lowest on the market. Finally, the concentration of OmegaRx 2 is among the highest concentration of any non-prescription omega-3 fatty acid product on the market. 

How much fish oil do you recommend people take?
I recommend taking a daily minimum of 3 grams of EPA and DHA. That said, we use our Cellular Inflammation test to determine the ideal amount an individual requires. This test looks at the ratio of two key fatty acids in the blood: Arachidonic Acid (AA), an omega-6 fatty acid which is the building block for pro-inflammatory hormones, and EPA which is the building block for pro-resolution hormones. The AA/EPA ratio or Cellular inflammation Score will tell you with the most precision how much you need to take on a daily basis to optimize your overall wellness. It has been demonstrated that decreasing the AA/EPA ratio is strongly associated with a longer life. 

If my cellular inflammation score is ideal, do I need the heightened concentration? 
If your Cellular Inflammation Score is between 1.5 to 3 you are in the ideal range to promote future wellness.  The higher the Cellular Inflammation Score, the more inflamed you are.  The average American has a Cellular Inflammation Score of 20.  Resolution of inflammation is key to maintaining wellness, and this can only be achieved with a lower score.  It is possible to achieve an ideal AA/ EPA ratio or Cellular Inflammation Score within 30 days with the correct dosage of OmegaRx 2.

When will people start seeing the benefits after they begin to supplement and what will they be?
I generally tell people that it takes about 30 days to truly see the impact of supplementation in the blood, but it's only a matter of days that their benefits subside once you stop taking them. This means you have to be consistent with your intake of purified fish oils and take it daily. Omega-3 fatty acids have been shown to help support a healthy heart, brain function, behavior and mood regulation, cellular rejuvenation, athletic performance and recovery, and improved vision. Their benefits are due to their role in resolving excess cellular inflammation.

Do you have tips for how to take it? 
Most people do just fine taking our recommended dose of 4 capsules or 1 teaspoon of OmegaRx 2 daily. I always suggest taking it with food and if you want to split up your dose between morning and night to see how you do that is fine too. 

How long do you have to take it?
For a lifetime if you want to maintain wellness. Once you stop taking omega-3 fatty acids your levels of omega-3s will soon return to baseline within a few days.

What are the benefits of omega-3 fatty acids across the lifespan?

Fish oil or omega-3 fatty acids are critical across the lifespan. This is why they are essential nutrients.  It starts in the womb as they support brain development in utero in addition to minimizing post-partum depression for the mother. We now know that the dietary and metabolic environment the fetus is exposed to in the womb can echo through the rest of his or her so it’s critical to have good nutrition and adequate levels of omega-3s throughout pregnancy and after. The rise in conditions such as autism, ADHD, diabetes and heart disease in early childhood and young adulthood may have a connection with the high levels of omega-6 fatty acids in our diet and low amounts of omega-3s. I strongly believe that chronic conditions associated with aging such as heart disease, diabetes, cancer, and dementia start with the failure to resolve inflammation so by getting adequate levels of omega-3s early on you can help to promote a lifetime of wellness.  {{cta('70a4b644-a93c-4f8b-83ec-5be1500ed236')}}

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022724---Weight-Loss-Blog

Dr. Sears Q&A: Weight Loss

With so much interest in weight loss and so much buzz around weight loss drugs, we put together some of the top questions we get in this latest Q&A blog. Here Dr. Sears answers your questions on weight loss, weight loss drugs and what he thinks is the most scientifically backed way to lose weight. See what he has to say.Question: What medical conditions could impede weight loss, and how can they be identified?  Answer:  Any condition associated with insulin resistance will make it difficult to lose weight.  This would include diabetes, heart disease, neurological disease, etc.  Also, any drug that induces insulin resistance will also make it difficult to lose weight.  These include corticosteroids and many neurological drugs. Question: How do hormones affect weight loss, and which imbalances are most detrimental? Answer: High levels of insulin (caused by insulin resistance), high levels of cortisol (caused by stress), and low levels of satiety hormones such as GLP-1 will make weight loss difficult. Question: Is there a connection between sleep quality and weight loss? Answer: Poor quality sleep increases cortisol levels that lead to insulin resistance. The higher your level of insulin resistance, the more difficult it is for any organ to remove glucose from the blood for transport into the cell, where it can be converted to energy. This i Question: Do any weight loss supplements work?  Answer: Not really. You have to restrict calories to activate AMPK which causes your body to effectively burn excess stored body fat.   Question: What medications are FDA approved for weight loss? Answer: There are number of approved older drugs, but the most widely used is still an old drug (Phentermine) that was only recently approved for long-term use. However, the new injectable GLP-1 receptor agonists are more powerful and more popular. The scientific name for the most well-known injectable weight-loss drug is semaglutide, which is marketed under the tradenames Ozempic and Wegovy. In simple terms, these injectable drugs activate the release of the hormone GLP-1 from the gut that goes directly to the brain to tell you to stop eating. These drugs were initially developed to treat type 2 diabetes, but the clinical studies in overweight and obese individuals demonstrated significant weight loss at higher levels. Question: What are the unintended side effects of weight loss medications (i.e. GLP-1s, dual GIP/GLP-1). Answer: One major problem is that the lack of hunger caused by the drug makes you less likely to consume sufficient protein to maintain lean body mass.  Lean body mass is defined as functional tissue such as organs (including the brain) and bone.  Nearly 40 percent of the weight loss in obese patients comes from loss of lean body mass.  Without adequate protein (especially on a diet that is calorie-restricted because of lack of hunger), the replacement of damaged cells is compromised.  The skin and hair are the first site to suffer.  This lack of protein also makes it difficult to maintain mitochondrial function that provides energy for each of your 30 trillion cells. As a result, fatigue (both mental and physical) is often experienced. Question: Would you recommend an injectable weight loss drug? Answer: The answer is no. There is a big difference between weight loss and fat loss. Weight loss is the combined loss of stored body fat and lean body mass (i.e., muscle). You want to lose fat but not muscle. Although the weight loss using weekly semaglutide injections is impressive according to the literature, a deeper look shows that about 40 percent of that weight loss is due to loss of lean body mass. That is not a good sign. It suggests that the injections reduce hunger to the extent that the person has little desire to eat enough protein to maintain muscle mass. In essence, the drug increases the patients' sarcopenia (muscle loss). One of the consequences of sarcopenia is increased frailty. Also once you stop using these weight loss drugs, the weight quickly returns. Question: Does a high protein diet help with weight loss? Answer: Most high protein diets are ketogenic diets that disrupt metabolism in addition to being high fat.  The appropriate diet is protein-adequate (about 30 grams of protein at each meal), carbohydrate-moderate (primarily non-starchy vegetables, low-fat (to reduce calories) and rich in fermentable fiber.  The common name for such a diet is the Zone diet. The ideal amount of protein at each meal for weight loss is about 30 grams. Less than 30 grams of protein at meal will not generate the hormonal signals from the gut to stop hunger. Too much protein at meal, greater than 30 grams, will inhibit AMPK activity which helps cells burn excess stored fat.  

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020524-Winter-E-Newsletter-Blog-4

Aging: Can You Slow It Down?

The first few weeks of the New Year are often focused on the resolve to lose weight, when in actuality people should focus their goals on slowing down aging, no matter the time of year. The only regimen that clinically achieves results in slowing the aging process is calorie restriction without malnutrition. Why? It’s not simply losing weight but orchestrating the complex interplay of reducing senescent cells, reprograming your metabolism, and changing gene expression, leading to a longer and better life.   A Timeline of Calorie Restriction   The first recorded human experiments with calorie restriction began with the written books of Luigi Cornaro in the 16th century, as I outlined in my book The Anti-Aging Zone, published in 1999. However, the molecular mechanisms of why calorie restriction is so effective required more recent breakthroughs in metabolism and epigenetics that were confirmed with the CALERIE study that carefully controlled the diets of 225 participants over two years and then ongoing testing of their retained blood samples.     The results of the CALERIE study have been impressive. However, the one clear take-home lesson was that reduction of insulin resistance was the most predictive blood marker correlated with the genetic changes and the decrease in senescent cells that ultimately accelerate aging.   The Zone on Calorie Restriction   The Zone diet is a calorie-restricted diet that was patented to reduce insulin resistance. It requires balancing macronutrients at each meal to generate the rapid hormonal changes that give rise to satiety. Only then can you follow calorie restriction for a lifetime without hunger and fatigue. It starts with having enough protein at each meal to create satiety in the brain's appetite control center. You need about 30 grams of protein (no more, but no less) at each meal to generate the same hormonal responses induced by the recent injectable weight loss drugs. However, you also must balance that protein with an adequate level of low-glycemic carbohydrates (about 40 grams) to stabilize blood glucose levels, and then add a dash of monounsaturated fat (about 15 grams). Over the years, it has been demonstrated by more than 40 research publications that the Zone diet is superior to ketogenic diets and the Mediterranean diet under controlled clinical research.    A New Technology to Slow Down Aging  Unfortunately, many people think the Zone diet requires too much thinking.  That’s why I developed Zone Foods to overcome that problem. The first generation of Zone Foods demonstrated dramatic reductions in insulin resistance compared to a control group, getting an equal number of calories (1). The second generation of Zone Foods offers greater variety and even more appetite suppression without thinking. This second generation will include new and improved versions of the Zone Pasta and Zone Bars, with new additions of Zone Muffins, Zone Oatmeal, Zone Granola, Zone Soups, and Zone Cookies (coming soon!). Each Zone Food contains 15 grams of protein, balanced with the appropriate level of low-glycemic carbohydrates, so any combination of two Zone Foods will provide the critical 30 grams of protein at a meal to stop hunger and maintain peak mental awareness for the next five hours. The growing variety of Zone Foods makes following the Zone diet incredibly easy. If you are never hungry, that indicates that you are reducing insulin resistance. The long-term benefit to you is slowing aging, which is only possible with lifelong use of Metabolic Engineering that starts with the Zone diet as its foundation. You May Also Like: Reaching the Zone Using Metabolic Engineering

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