Zone Labs Cellular Inflammation Test Kit

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4.5
Rated 4.5 out of 5 stars
75 Reviews

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The Details

If your level of cellular inflammation is high, the body begins attacking itself. If it is too low, then your body can’t fight off microbial invaders effectively. You need to keep the body’s level of cellular inflammation in a zone. Elevated levels of cellular inflammation are the underlying cause of why we gain weight, develop chronic disease, and age at a faster rate. What is Cellular Inflammation? Cellular inflammation is the type of inflammation that is below the perception of pain. What it does is disrupt hormonal signaling at the cellular levels that leads to increased fat accumulation, acceleration of the development of chronic disease, and decreased physical performance. You can’t feel cellular inflammation, but you can measure it. The only way to measure cellular inflammation is by testing the ratio of two essential fatty acids (AA and EPA) in your blood. What is the AA/EPA Ratio? The AA/EPA ratio is an indication of the levels of cellular inflammation in...
If your level of cellular inflammation is high, the body begins attacking itself. If it is too low, then your body can’t fight off microbial invaders effectively. You need to keep the body’s level of cellular inflammation in a zone. Elevated levels of cellular inflammation are the underlying cause of why we gain weight, develop chronic disease, and age at a faster rate.

What is Cellular Inflammation?
Cellular inflammation is the type of inflammation that is below the perception of pain. What it does is disrupt hormonal signaling at the cellular levels that leads to increased fat accumulation, acceleration of the development of chronic disease, and decreased physical performance. You can’t feel cellular inflammation, but you can measure it. The only way to measure cellular inflammation is by testing the ratio of two essential fatty acids (AA and EPA) in your blood.

What is the AA/EPA Ratio?
The AA/EPA ratio is an indication of the levels of cellular inflammation in your body. High levels of cellular inflammation does not mean you have a disease state, but it does indicate that you are not as well as you could be. Your future state of wellness can be determined by the levels of cellular inflammation in the blood as shown below. 
AA/EPA RangesCellular InflammationFuture state of wellness
1.5 to 3LowExcellent
3 to 6ModerateGood
7 to 15ElevatedModerate
> than 15HighPoor
The higher your levels of cellular inflammation, the more likely the future development of chronic disease will be accelerated. A recent study from Italy has demonstrated that the AA/EPA ratio is always greater than 15 in patients with chronic diseases (1).

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This simple finger-stick blood test measures the levels of two key fatty acids in the blood, Arachidonic Acid (AA) an omega-6 fatty acid and Eicosapentaenoic Acid (EPA), an omega-3 fatty acid.

The average American has a score of approximately 20 but to be considered well Dr. Barry Sears recommends you be between 1.5 and 3. Don’t guess about cellular inflammation. Taking a painless fingertip blood test is the only way to know if you have high levels of cellular inflammation.
How it works:
  1. COLLECT SAMPLE - Follow the step-by-step instructions to collect your sample.
  2. MAIL SAMPLE - Put your sample in the return envelope and drop it in the mail.
  3. GET RESULTS - In 2-3 weeks you will get your personalized results by email.
  4. MODIFY DIET - Review your results and make necessary changes to your diet based on the recommendations.

Use recommendations included with your results to modify diet.
Notes: Test available in U.S. and internationally. However, New York state law prohibits the distribution of blood testing kits from Zone Labs. Therefore we are unable to process Internet orders from customers in New York at this time. Due to safety standards associated with medical products, the Zone Labs Cellular Inflammation Test Kit is exempt from our 30-day return policy.
The Details
The Details
We all desire to have a clinical marker of our future state of wellness. It is my opinion that the AA/EPA ratio in the blood is the best marker of that elusive goal because it measures the level of cellular inflammation in the body. Dietary Methods to Improve the AA/EPA Ratio There are no drugs that can change the AA/EPA ratio. This is because the AA/EPA ratio is a consequence of the diet. One method of lowering the AA/EPA ratio is to increase the intake of high-purity omega-3 fatty acid concentrates rich in EPA. This will increase the EPA content in the blood (2). This represents the fastest way to reduce the AA/EPA ratio. However, the best long-term method is to reduce the AA levels in the blood. This is best achieved by following a strict anti-inflammatory diet, such as the Zone Diet (3-5). The Zone diet was designed to reduce elevated levels of both insulin and omega-6 fatty acids so that the production of AA is significantly reduced. The combination of an anti...
We all desire to have a clinical marker of our future state of wellness. It is my opinion that the AA/EPA ratio in the blood is the best marker of that elusive goal because it measures the level of cellular inflammation in the body.

Dietary Methods to Improve the AA/EPA Ratio
There are no drugs that can change the AA/EPA ratio. This is because the AA/EPA ratio is a consequence of the diet. One method of lowering the AA/EPA ratio is to increase the intake of high-purity omega-3 fatty acid concentrates rich in EPA. This will increase the EPA content in the blood (2). This represents the fastest way to reduce the AA/EPA ratio. However, the best long-term method is to reduce the AA levels in the blood. This is best achieved by following a strict anti-inflammatory diet, such as the Zone Diet (3-5). The Zone diet was designed to reduce elevated levels of both insulin and omega-6 fatty acids so that the production of AA is significantly reduced. The combination of an anti-inflammatory diet coupled with high-purity omega-3 concentrations represents the most powerful dietary approach to reach and maintain a low level of cellular inflammation for a lifetime.

How much EPA and DHA do I have to take to reduce the AA/EPA ratio?
A recent dose-response study in healthy women who had a high risk for potential breast cancer has provided supplementation guidelines for reduction of the AA/EPA ratio (5). 
Grams of EPA and DHA supplemented per day AA/EPA Ratio
0 12.1
0.8 4.7
2.5 2.6
5.0 1.3
7.5 1.2
This data indicates that a daily dosage of EPA and DHA of 2.5 grams was sufficient to bring the AA/EPA ratio into the desired range for excellent wellness for these healthy individuals. This level of EPA and DHA recommendation correlates well with an Italian study that demonstrated in patients with various chronic diseases having an elevated AA/EPA ratio (>15) lowered their elevated AA/EPA ratio to approximately 5 with daily supplementation of 2.5 grams of EPA and DHA (1). This is also indicative that a person with an existing chronic disease may need greater amounts of EPA and DHA to get them into an excellent wellness range compared to a healthy individual.
However, these are only general guidelines for daily EPA and DHA supplementation. The best indication of the amount of EPA and DHA required to optimize the AA/EPA ratio for an individual is best determined with blood testing every six to twelve months.

The benefits of reduction of the AA/EPA ratio.
The JELIS study was one of the largest cardiovascular studies ever done using more than 18,000 subjects with elevated cholesterol levels. When these subjects were given high doses of EPA (1.8 grams of EPA per day), their average AA/EPA ratio decreased from 1.6 to 0.8. This reduction in the AA/EPA ratio was associated with an additional 19% reduction in cardiovascular events during the next four and half years (7).Until there is more data, I do not believe it prudent to reduce the AA/EPA ratio to less than 1.5 even through significant cardiovascular benefits do occur at lower AA/EPA ratios in patients with elevated cholesterol levels as demonstrated in the JELIS study.

References:
  1. Rizzo AM, Montorfano G, Negroni M, Adorni L, Berselli P, Corsetto P, Wahle K, and Berra B. “A rapid method for determining arachidonic:eicosapentaenoic acid ratios in whole blood lipids: correlation with erythrocyte membrane ratios and validation in a large Italian population of various ages and pathologies.” Lipids in Health and Disease 9:7 (2010)
  2. Sears B. The OmegaRx Zone. Regan Books. New York, NY (2002)
  3. Sears B. The Zone. Regan Books. New York, NY (1995)
  4. Sears B. The Anti-Inflammation Zone. Regan Books. New York, NY (2005)
  5. Sears B. Toxic Fat. Thomas Nelson. Nashville, TN (2008)
  6. Yee LD, Lester JL, Cole RM, Richardson JR, Hsu JC, Li Y, Lehman A, Belury MA, and Clinton SK. “Omega-3 fatty acid supplements in women at high risk of breast cancer have dose-dependent effects on breast adipose tissue fatty acid composition.” Am J Clin Nutr 91: 1185-1194 (2010)
  7. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T, Kitabatake A, Nakaya N, Sakata T, Shimada K, and Shirato K. “Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis.” Lancet 369: 1090-1098 (2007)
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The Details

Real reviews, from real people.

See what our customers have to say about Zone products.

4.5
Rated 4.5 out of 5 stars
Based on 75 reviews
Total 5 star reviews: 54 Total 4 star reviews: 13 Total 3 star reviews: 2 Total 2 star reviews: 3 Total 1 star reviews: 3
89%would recommend this product
75 reviews
  • AV
    Adriana V.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    12 seconds ago
    Excellent

    Waiting for results for my son FIRAT who tested on Jan 21st

    We as a family have been using it yearly and it’s a great tool to check your immune system

    Adriana vink

  • MK
    Mark K.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 week ago
    Part Of An Overall Health Assement

    The test kit itself is simple to use and convenient. The results give you an indication of inflamation on a cellular level which is an indicator of how healthy your diet is. It’s part of an overall health assement you won’t get from your doctor in most cases.

  • MW
    Martha W.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    3 months ago
    Great to do!

    Love the way I can just do this at home and mail it and get the results right in my email. Also wonderful that you can call and talk to Mary about your results if you meed to. Easy to follow imstructions with all the supplies you need.

  • BR
    Barbara R.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    3 months ago
    Know your inflammation score

    The kit comes with very clear instructions and is easy to use. It is a great way to learn the direction your health is taking.

  • WW
    William W.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    3 months ago
    Zone Purchase

    I love this product.

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