All Recipes All Zone Living Articles
0920-MaquiRx-Blog--

Maqui: Learn Why This Berry Is The Best Of The Best

The real secret of nutrition is understanding how the food we eat is transformed into complex signaling molecules that keep us alive. Dietary amino acids and fatty acids can be converted into hormones (such as insulin and resolvins) that control our bodies with precision. Likewise, polyphenols are also part of such signaling systems. In particular, they activate the genetic master switch of metabolism known as AMPK that controls how we generate energy and regulate our metabolism by turning it on and off at the cellular level.

If you want to maintain wellness, you have to optimize your Resolution Response, as I describe in my newest book, The Resolution Zone. A critical step in that optimization is the activation AMPK, the genetic master switch for your metabolism. Polyphenols give you the dietary tools to do this—the reason why is shown in the following figure.

Protection-from-Polyphenols--

There are more than 8,000 known polyphenols, but not all have the same ability to activate AMPK. The reason is that it depends on several factors, including concentration, structure, water-solubility, and degree of polymerization.

Concentration

              Polyphenols are found in exceptionally low concentrations in fruits and vegetables; perhaps 0.2 percent by weight in fruits and about 0.1 percent by weight in vegetables. Since you need at least about 1,000 mg of polyphenols per day, it means you have to consume a lot of fruits and vegetables. How much is a lot? About ten servings per day. Not surprisingly, those individuals who consume this level of fruits and vegetables live longer. How much longer? Those that consume ten servings per day live about 30 percent longer with significantly less heart disease and cancer (1). Unfortunately, for most Americans, eating this amount of fruits and vegetables seems like Mission Impossible.

Structure

              There are two broad classes of polyphenols—those that have a fused ring structure and those that don’t. The differences are shown below between the two general categories of polyphenols.Figure1-0

              It is only the polyphenol class known as flavonoids that have a fused ring structure that provides the appropriate three-dimensional properties to activate AMPK maximally. The other polyphenol structures are simply too floppy in three-dimensional space to do an excellent job of activating AMPK. This structure deficiency is especially true of resveratrol, which is part of the stilbene family of polyphenols.

              Even within the class of the fused-ring polyphenols (i.e., flavonoids), there are a lot of variations, as shown below.

Figure5-0

              If you look closely at this figure, you will see that flavanols look somewhat similar to anthocyanins. Chocolate is rich in flavanols, whereas berries are rich in anthocyanins. But there is a big difference in their water solubility between these two groups of polyphenols.

Water-solubility

              Although flavanols and anthocyanins are somewhat similar in structure, there are significant differences in their water-solubility. This difference is because the anthocyanins have a positive charge to make them much more water-soluble. This water-solubility is critical since it has been shown that it is the increased consumption of anthocyanins that are most associated with the reduction of heart disease (2,3).

The water solubility of polyphenols is critical because if they don’t get in your body, they can’t activate AMPK. And if you don’t activate AMPK, you can’t have an optimal Resolution Response.

              Not surprisingly, there are a lot of different structures, even within anthocyanins, as shown below:Figure3--00

              In addition to having a positive charge, the more hydroxyl groups (-OH) on an anthocyanin molecule only further increases its water-solubility. This unique structure is why the subclass of anthocyanins, known as delphinidins, has the highest water-solubility of all anthocyanins.

              Although colorful berries are the richest source of anthocyanins, not all berries are good sources of delphinidins. As an example, strawberries are rich in anthocyanins, but they contain no delphinidins. Raspberries have a minimal amount of delphinidins, but not nearly as much as blueberries. However, even within the blueberry family there are significant variations. Bilberries (grown in northern Europe) have six times more delphinidins than blueberries (grown in North America). However, the maqui berry (grown in southern Chile) has 14 times the concentration of delphinidins compared to blueberries.

However, there is another problem to overcome; the degree of polymerization of the delphinidins within these natural sources.

Polymerization

              Most natural sources that contain delphinidins are composed of polymers. Polymers can’t be directly absorbed into the bloodstream. As a result, they continue to the colon where the gut bacteria metabolize them to shorter fragments that no longer contain the critical fused-ring structure. To get a maximum benefit for activating AMPK, you need the fused ring structure to provide the proper three-dimensional structure.

Extracts

              Even for the maqui berry, the absolute levels of delphinidins as monomers in the fruit are still relatively low. This concentration problem can be circumvented by making extracts of the maqui berry using extensive purification, including column chromatography, to get a highly concentrated extract of delphinidin monomers. This purified maqui berry extract is what we use to make MaquiRx.

              For comparison, you would need to consume 4.5 kg of raspberries to get the same absolute levels of delphinidins as one capsule of MaquiRx. Alternatively, you could drink 50 glasses of red wine. Even though 200 grams of blueberries may have the same absolute levels of delphinidins as one capsule of MaquiRx, most of those delphinidins in blueberries are polymers that will not be directly absorbed into the body. On the other hand, the purified delphinidin monomers found in MaquiRx are directly absorbed into the blood (4).

Summary

             It is easy to be confused about which 8,000 polyphenols will help you live longer. If you are looking for the best of the best of those 8,000 polyphenols, then your choice becomes much less complicated using MaquiRx as your primary polyphenol supplement. MaquiRx is the only polyphenol supplement that meets the criteria of concentration, structure, water-solubility, and degree of polymerization that you need to activate AMPK. Supplementing your diet with MaquiRx doesn’t mean you ignore the continuing need to consume up to 10 servings of fruits and vegetables per day, as suggested by following the Zone Diet because they are crucial for gut health as well as blood sugar and appetite control. The combination of these two dietary strategies (following the Zone Diet supplemented with MaquiRx) provides a pretty good pathway for a longer and better life.

CTA-Maq-1

References

  1. Aune D et al. “Fruit and vegetable intake and the risk of cardiovascular disease, total cancer, and all-cause mortality-a systematic review and dose-response meta-analysis of prospective studies.” Int J Epidemiol 46:1 029-1056 (2017)
  2. Kimble R et al. “Dietary intake of anthocyanins and risk of cardiovascular disease: A systematic review and meta-analysis of prospective cohort studies.” Crit Rev Food Sci Nutr 59: 3032-3043 (2019)
  3. Cassidy A et al. “High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women.” Circulation 127:1 88-196 (2013)
  4. Schon C et al. “Bioavailability study of maqui berry extract in healthy subjects.” Nutrients 10(11):1720 (2018)

 

 

More Articles

062524---Keto-Blog

Ketogenic Diets and Aging

Chances are, you or someone you know has tried the keto diet at some point in time. This high-fat, very low-carbohydrate eating plan appeals to many due to its promise of rapid weight loss. In this blog, Dr. Sears explores some of the latest scientific findings on ketogenic diets and provides caution before hopping on this trend. What is a Ketogenic Diet? The ketogenic diet is a high-fat, very low-carbohydrate eating plan. This significant reduction in carbohydrates to induce a metabolic state is called ketosis. This only occurs when there is not enough carbohydrates in your liver to completely convert fatty acids to carbon dioxide and water. The normal conversion generates the chemical energy (ATP) that keeps us alive. In the absence of ketosis, each fatty acid generates 108 molecules of ATP when oxidized in the mitochondria. Ketone bodies make less ATP when they are metabolized by mitochondria. How much less? About five times less. This is like switching the gasoline in your car from high-octane fuel to low octane fuel as ketone bodies increase in the blood. Furthermore, contrary to popular belief, ketones are not an ideal energy source for the brain, as glucose remains the preferred fuel for ATP production in brain cells. Lack of blood glucose is a highly stressful situation for the brain. This is why the body secretes the stress hormone cortisol from the adrenal glands during ketosis to breakdown protein and convert the amino acids into glucose for the brain. This explains why even under complete starvation for 38 days, the blood glucose levels never dropped below 68 mg/dL. This is still considered as a normal blood sugar level. Where did this blood glucose come from if there was none in the diet for 38 days? The answer is neo-glucogenesis primarily using lean body mass. Ketogenic Diets Pros and Cons Interest in ketogenic diets rises and falls about every 20 years. They’re very low-carbohydrate diets that claim that carbohydrates make you fat and keep you fat. This is simply not true. It is not carbohydrates per se but a disrupted metabolism that makes you fat. To be more specific, it is the inhibition of AMPK, the master regulator of your metabolism that makes you fat. Why? As AMPK activity increases, you burn stored fat faster. Frankly, I’ve always been amazed by the re-emergence of ketogenic diets. Eighteen years ago, I published the premier clinical study demonstrating that, under equal calorie intake in which all the food was provided to the subjects for six weeks, the Zone Diet was better than a ketogenic diet in reducing total weight, excess body fat, and inflammation. Now, a recent study revealed some more very concerning findings about the long-term effects of ketogenic diets. This new study indicated that following a keto diet causes a rise in senescent cells, popularly known as “zombie cells.” Zombie Cells are damaged cells that no longer divide but don't die. That’s bad enough, but zombie cells continue spreading inflammation throughout the body. As the number of zombie cells increases in your body, they become a living nightmare. Why? Zombie cells accelerate aging because they cause the earlier development of many chronic diseases. In this study they found that zombie cells in the animals began to appear while they were on a ketogenic diet. The zombie cells then disappeared when researchers changed the diet to a “non-ketogenic diet” (i.e., the Zone diet). And when the animals were given a Keto diet again, the zombie cells reappeared. Notice a trend? If you want to hear more about this study you can listen to our recent podcast at Dr.Sears.com. Based on earlier blogs, this adds to the list of downsides for following a ketogenic diet versus the Zone Diet. PROS Rapid initial weight loss: This is primarily due to the loss of retained water from the glycogen stores in the liver, which is rapidly used up to maintain blood sugar levels. Since these glycogen stores in the liver contain significant levels of retained water, much of the initial weight loss is water rather than stored body fat. If your main goal is loss retained water, this can be seen as a benefit. Of course, going to a sauna would also work. Reduced hunger: Ketogenic diets are rich in protein. Any increase in protein intake can help reduce hunger. CONS Production of acetone: One of the ketone bodies produced during ketosis is acetone, which is also the main chemical in nail polish. Increased calcium loss: A ketogenic diet can lead to higher calcium loss from bones. Limited fat utilization: High levels of dietary fat reduce the likelihood of using stored body fat for energy unless you also significantly restrict calories. Reduced energy levels: The lack of ATP production on a ketogenic diet can lead to easier fatigue during mild exercise. Damage from cheat meals: After seven days on a keto diet, a single high-carb cheat meal can damage blood vessels. Lack of polyphenols: This makes it difficult to activate genes that optimize metabolism by improving mitochondrial efficiency in converting fat into ATP. No long-term weight loss advantage: Long-term studies show no difference in weight loss between a ketogenic diet and a low-fat, high-carb diet. No short-term metabolic advantage: Careful studies demonstrate that fat loss on a ketogenic diet is the same as on a low-fat, high-carb diet with the same caloric intake. Compromised gut health: A lack of fermentable fiber from carbohydrates can lead to poor gut health and an increased risk of developing a leaky gut, which can cause significant inflammation. Furthermore, short-chain fatty acids (SCFA) are the metabolic product of fermentable fiber. These SCFA are powerful epigenetic signaling agents that enhance gene transcription. Ketosis generates a different type of hydroxylated short fatty acid (3-hydroxyl butyrate, that has no effect on gene transcription. In addition, the lack of SCFA has significant negative consequences on the gut-brain axis. Cortisol build-up: To produce glucose for the brain, cortisol levels increase to breakdown protein to make sufficient glucose via neoglucogenesis. Excess cortisol can lead to insulin resistance that cause regain of some of initially loss body fat. In addition, increased cortisol levels cause a depressed immune system as well as destruction of memory cells in the hippocampus. The initial benefits of following the ketogenic diet result in some initial weight loss (primarily water weight rather than fat loss), long-term studies show no significant differences in overall weight loss. Now new findings show a ketogenic diet may lead to significant adverse health consequences by accelerating the formation of zombie cells. Call me crazy, but I feel the key to longevity and wellness comes down to better metabolic control instead of living in a constant state of ketosis. Following Metabolic Engineering® for a lifetime provides that pathway of losing body fat without ketosis. References 1. Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, and Sears B. “Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets.” Am J Clin Nutr 2006 83:1055-61. 2. White AM, Johnston CS, Swan PD, Tjonn SL, and Sears B. “Blood ketones are directly related to fatigue and perceived effort during exercise in overweight adults adhering to low-carbohydrate diets for weight loss: a pilot study.” J Am Diet Assoc. 2007 107:1792-1796. 3. Sung-Jen Wei, Joseph R Schell, E Sandra Chocron, Mahboubeh Varmazyad, Guogang Xu, Wan Hsi Chen, Gloria M Martinez, Felix F Dong, Prethish Sreenivas, Rolando Trevino Jr , Haiyan Jiang, Yan Du, Afaf Saliba, Wei Qian, Brandon Lorenzana, Alia Nazarullah, Jenny Chang, Kumar Sharma, Erin Munkácsy, Nobuo Horikoshi, David Gius. Ketogenic diet induces p53-dependent cellular senescence in multiple organs. Sci Adv. 2024 May 17;10(20):eado1463. doi: 10.1126/sciadv.ado1463. 4. Owen OE, Felig P, Morgan AP, Wahren J, Cahill GF Jr. Liver and kidney metabolism during prolonged starvation. J Clin Invest. 1969 Mar;48(3):574-83. doi: 10.1172/JCI106016. 5. Chriett, S., Dąbek, A., Wojtala, M. et al. Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule. Sci Rep 9, 742 (2019). https://doi.org/10.1038/s41598-018-36941-9. 6. Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020 Jan 31;11:25. doi: 10.3389/fendo.2020.00025. 

View Article
050824---Tofu-Blog

Tofu: Tips and Recipes Ideas

I have been eating tofu for a very long time, much longer than the 30 or so years I have been following the Zone Diet. Back then many of my favorite recipes came from the Tassajara cookbooks by Edward Espe Brown, the celebrated chef from the kitchen at California’s famous Zen Mountain Center, and cookbooks by Louise Hagler, a.k.a. Wendy Louise, a well-known authority on vegetarian cooking who is associated with a community in Tennessee known as The Farm. Those books are still among the best resources for tofu recipes. My mantra has always been if you don’t like something, don’t eat it. Keep this in mind if you’re new to tofu, start slowly by combining it with flavors and foods you like.    Tips and Suggestions    Firm-sprouted tofu is my preference for the Zone Diet. Unlike traditional tofu, which contains significant amounts of both protein and carbohydrate, sprouted has almost no carbohydrates. It’s lighter tasting, refreshing, and very filling.   Freezing tofu results in a chewy, sponge-like texture. I don’t recommend freezing, but some people prefer it when using tofu to substitute for meat in a recipe.    Baked tofu comes in a variety of flavors and makes an excellent quick meal with some vegetables and fruit added. It’s also great in salads.     Tofu made it into the book “The Top 100 Zone Foods” by Barry Sears.    Some recipes call for draining the tofu first. I find that usually isn’t necessary.   Tofu takes on the flavor of whatever is added to it.    Add nutritional yeast flakes to give a cheesy flavor to vegan tofu scrambles and dips. It’s also rich in protein and vitamin B12.   Cherry Vanilla Tofu “Ice Cream”   Tip: This doesn’t freeze or store well, so prepare only the amount you plan to serve immediately.   Using an immersion blender or a food processor blend equal parts of frozen dark cherries and firm tofu, plus some vanilla extract (preferably alcohol-free for best flavor). Serve immediately.  Tofu Scramble  This is great for breakfast, lunch, or dinner, and we’ve even brought it on long day hikes for a snack.   Crumble some firm tofu and stir in a generous amount of seasonings, taking care not to overdo it with the salt. Heat in a well-seasoned or nonstick skillet with a little Zone-friendly oil to the desired doneness.    Optional: If time allows, sauté some chopped onion in the skillet before adding the tofu and seasonings.    My favorite seasoning combination for this dish at my house is onion powder, garlic powder, turmeric, paprika, some oregano or thyme, nutritional yeast flakes, salt, and ground black pepper. The yellow color of the turmeric makes it somewhat like scrambled eggs.   Tofu Veggie Almond Pasta Salad   Dressing: Thin some smooth almond butter by stirring in some water, a little vinegar, and either soy sauce or Bragg’s Liquid Aminos (an unfermented soy sauce found in the health food section of most grocery stores).    Toss together cooked Dr. Sears’ Zone PastaRx Fusilli, tofu cut into cubes, matchstick cut red bell pepper, chopped green parts of scallions (a.k.a. green onions), and the almond butter dressing. Serve immediately or chill to serve later. It will keep well in the fridge for two or three days.   Use your imagination and see what you can come up with.  Experiment and have fun with it. Try using tofu to make cheesecakes, whipped desserts, tofu chocolate pudding, tofu “cream” based soups, tofu pot pie (think chicken pot pie), tofu burgers, tofu burritos, Buffalo tofu (like Buffalo wings), layered Mediterranean dips, tofu “meatballs”, grilled tofu, and more.    Enjoy! 

View Article