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The Importance of Breakfast

We’ve heard it time and time again that breakfast is the most important meal of the day, but is that true? One of the biggest benefits to consuming breakfast is to replenish energy stores and to stabilize hormones. After a full night’s sleep our blood sugar level is low and by early morning our liver glycogen stores have been depleted in an effort to maintain blood glucose throughout the night. Once energy stores are exhausted, blood glucose and insulin levels begin to drop and as a result the stress hormone cortisol is released. Cortisol levels naturally rise in the morning, but it's release signals the body to begin breaking down muscle for energy. This is why it’s critical to eat an appropriate breakfast to restore blood sugar levels and replenish glycogen. By skipping breakfast cortisol levels stay elevated until the next meal resulting in the increased breakdown of muscle for energy.

SummerSeries-BreakfastSwaps-HeaderWhy a Zone Breakfast

The Zone is based on keeping your insulin levels in a zone that is not too high and not too low. This will stabilize blood sugar and prevent the continued breakdown of muscle for energy. Eating a Zone breakfast can help keep your insulin levels stable, provide the necessary protein to prevent hunger and replenish the levels of liver glycogen. It is important that the breaking down (catabolism) that happens overnight is balanced with the building up in the morning (anabolism). It is this balance that makes breakfast important for starting your day out right hormonally and sets the stage for the other benefits that come with eating breakfast such as improved alertness and productivity, increased cognition and memory, satiety, and weight control.

Zone Breakfast vs. Traditional Breakfast

Those who eat breakfast regularly have been shown to have higher intakes of vitamins and minerals and a more well-rounded diet. We always recommend eating a Zone breakfast within one hour of waking and having one with the right balance of lean protein, low-glycemic carbohydrates and a dash of monounsaturated fat. By keeping insulin levels balanced, Zone meals are the easiest way to keep your sugar cravings under control during the day. Doing so minimizes the need to constantly look for quick fixes when your energy levels start to plummet.

Breakfast Swaps

When looking for a Zone breakfast aim for one that is under 400 calories, with less than 12 grams of fat, 25 grams of protein and about 35 grams of net carbs (total carbohydrates minus fiber). Need an easy breakfast idea? Swap out your current breakfast for a ZoneRx Shake instead. Where most grab and go breakfasts fall short on protein, are high in carbs and added sugar, and can be high in fat, ZoneRx shakes have the precise balance you need to replenish your body coming off an overnight fast and to power you through to lunch. See how it compares.
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Dr. Sears Q&A: Weight Loss

With so much interest in weight loss and so much buzz around weight loss drugs, we put together some of the top questions we get in this latest Q&A blog. Here Dr. Sears answers your questions on weight loss, weight loss drugs and what he thinks is the most scientifically backed way to lose weight. See what he has to say.Question: What medical conditions could impede weight loss, and how can they be identified?  Answer:  Any condition associated with insulin resistance will make it difficult to lose weight.  This would include diabetes, heart disease, neurological disease, etc.  Also, any drug that induces insulin resistance will also make it difficult to lose weight.  These include corticosteroids and many neurological drugs. Question: How do hormones affect weight loss, and which imbalances are most detrimental? Answer: High levels of insulin (caused by insulin resistance), high levels of cortisol (caused by stress), and low levels of satiety hormones such as GLP-1 will make weight loss difficult. Question: Is there a connection between sleep quality and weight loss? Answer: Poor quality sleep increases cortisol levels that lead to insulin resistance. The higher your level of insulin resistance, the more difficult it is for any organ to remove glucose from the blood for transport into the cell, where it can be converted to energy. This i Question: Do any weight loss supplements work?  Answer: Not really. You have to restrict calories to activate AMPK which causes your body to effectively burn excess stored body fat.   Question: What medications are FDA approved for weight loss? Answer: There are number of approved older drugs, but the most widely used is still an old drug (Phentermine) that was only recently approved for long-term use. However, the new injectable GLP-1 receptor agonists are more powerful and more popular. The scientific name for the most well-known injectable weight-loss drug is semaglutide, which is marketed under the tradenames Ozempic and Wegovy. In simple terms, these injectable drugs activate the release of the hormone GLP-1 from the gut that goes directly to the brain to tell you to stop eating. These drugs were initially developed to treat type 2 diabetes, but the clinical studies in overweight and obese individuals demonstrated significant weight loss at higher levels. Question: What are the unintended side effects of weight loss medications (i.e. GLP-1s, dual GIP/GLP-1). Answer: One major problem is that the lack of hunger caused by the drug makes you less likely to consume sufficient protein to maintain lean body mass.  Lean body mass is defined as functional tissue such as organs (including the brain) and bone.  Nearly 40 percent of the weight loss in obese patients comes from loss of lean body mass.  Without adequate protein (especially on a diet that is calorie-restricted because of lack of hunger), the replacement of damaged cells is compromised.  The skin and hair are the first site to suffer.  This lack of protein also makes it difficult to maintain mitochondrial function that provides energy for each of your 30 trillion cells. As a result, fatigue (both mental and physical) is often experienced. Question: Would you recommend an injectable weight loss drug? Answer: The answer is no. There is a big difference between weight loss and fat loss. Weight loss is the combined loss of stored body fat and lean body mass (i.e., muscle). You want to lose fat but not muscle. Although the weight loss using weekly semaglutide injections is impressive according to the literature, a deeper look shows that about 40 percent of that weight loss is due to loss of lean body mass. That is not a good sign. It suggests that the injections reduce hunger to the extent that the person has little desire to eat enough protein to maintain muscle mass. In essence, the drug increases the patients' sarcopenia (muscle loss). One of the consequences of sarcopenia is increased frailty. Also once you stop using these weight loss drugs, the weight quickly returns. Question: Does a high protein diet help with weight loss? Answer: Most high protein diets are ketogenic diets that disrupt metabolism in addition to being high fat.  The appropriate diet is protein-adequate (about 30 grams of protein at each meal), carbohydrate-moderate (primarily non-starchy vegetables, low-fat (to reduce calories) and rich in fermentable fiber.  The common name for such a diet is the Zone diet. The ideal amount of protein at each meal for weight loss is about 30 grams. Less than 30 grams of protein at meal will not generate the hormonal signals from the gut to stop hunger. Too much protein at meal, greater than 30 grams, will inhibit AMPK activity which helps cells burn excess stored fat.  

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Aging: Can You Slow It Down?

The first few weeks of the New Year are often focused on the resolve to lose weight, when in actuality people should focus their goals on slowing down aging, no matter the time of year. The only regimen that clinically achieves results in slowing the aging process is calorie restriction without malnutrition. Why? It’s not simply losing weight but orchestrating the complex interplay of reducing senescent cells, reprograming your metabolism, and changing gene expression, leading to a longer and better life.   A Timeline of Calorie Restriction   The first recorded human experiments with calorie restriction began with the written books of Luigi Cornaro in the 16th century, as I outlined in my book The Anti-Aging Zone, published in 1999. However, the molecular mechanisms of why calorie restriction is so effective required more recent breakthroughs in metabolism and epigenetics that were confirmed with the CALERIE study that carefully controlled the diets of 225 participants over two years and then ongoing testing of their retained blood samples.     The results of the CALERIE study have been impressive. However, the one clear take-home lesson was that reduction of insulin resistance was the most predictive blood marker correlated with the genetic changes and the decrease in senescent cells that ultimately accelerate aging.   The Zone on Calorie Restriction   The Zone diet is a calorie-restricted diet that was patented to reduce insulin resistance. It requires balancing macronutrients at each meal to generate the rapid hormonal changes that give rise to satiety. Only then can you follow calorie restriction for a lifetime without hunger and fatigue. It starts with having enough protein at each meal to create satiety in the brain's appetite control center. You need about 30 grams of protein (no more, but no less) at each meal to generate the same hormonal responses induced by the recent injectable weight loss drugs. However, you also must balance that protein with an adequate level of low-glycemic carbohydrates (about 40 grams) to stabilize blood glucose levels, and then add a dash of monounsaturated fat (about 15 grams). Over the years, it has been demonstrated by more than 40 research publications that the Zone diet is superior to ketogenic diets and the Mediterranean diet under controlled clinical research.    A New Technology to Slow Down Aging  Unfortunately, many people think the Zone diet requires too much thinking.  That’s why I developed Zone Foods to overcome that problem. The first generation of Zone Foods demonstrated dramatic reductions in insulin resistance compared to a control group, getting an equal number of calories (1). The second generation of Zone Foods offers greater variety and even more appetite suppression without thinking. This second generation will include new and improved versions of the Zone Pasta and Zone Bars, with new additions of Zone Muffins, Zone Oatmeal, Zone Granola, Zone Soups, and Zone Cookies (coming soon!). Each Zone Food contains 15 grams of protein, balanced with the appropriate level of low-glycemic carbohydrates, so any combination of two Zone Foods will provide the critical 30 grams of protein at a meal to stop hunger and maintain peak mental awareness for the next five hours. The growing variety of Zone Foods makes following the Zone diet incredibly easy. If you are never hungry, that indicates that you are reducing insulin resistance. The long-term benefit to you is slowing aging, which is only possible with lifelong use of Metabolic Engineering that starts with the Zone diet as its foundation. You May Also Like: Reaching the Zone Using Metabolic Engineering

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